MINIMUM INHIBITORY CONCENTRATION LEVELS OF MUPIROCIN BY E-TEST AMONG STAPHYLOCOCCUS AUREUS ISOLATES AND THEIR ANTIMICROBIAL SUSCEPTIBILITY PATTERN

Objective: This study was done to evaluate the susceptibility of Staphylococcus aureus mupirocin and determine antimicrobial pattern among various clinical isolates. Methods: All consecutive, non-duplicative isolates collected during year 2020 were subjected disk diffusion method stocked. Mupirocin for all stocked detected by Minimal inhibitory concentration (MIC) determination Epsilometer test (E-test). Results: The total number 52. maximum isolated from pus sample 40 (76.9%). Among 52 isolates, 26 (50%) found be methicillin-resistant (MRSA). susceptible tetracycline (100%), vancomycin teicoplanin linezolid (100%). By E-test, overall prevalence resistance 63.5%. Low-level (MupRL) 8-256 µg/ml 59.6% high-level (MupRH) ≥512 3.9%. Conclusion: present shows a high (63.5%) which is serious concern. Therefore, indiscriminate use topical in carriers not advisable. It may recommended only case an outbreak skin soft tissue infection attributed aureus.